Paracetamol Dolo 650 – Uses, Side Effects, Composition and Price
What is Dolo 650?
Dolo 650 is a tablet that contains Paracetamol (also known as Acetaminophen) as its active ingredient. Each tablet contains 650 mg of paracetamol. It is classified under analgesics (pain relievers) and antipyretics (fever reducers).
Manufactured by Micro Labs Ltd, Dolo 650 has become a household name for its fast and effective relief from fever and pain.
Uses of Paracetamol Dolo 650
Dolo 650 is a versatile medicine used to treat a wide range of conditions. Some of the common uses include:
1. Fever
It helps in bringing down body temperature in cases of viral fever, bacterial infections, or post-vaccination fever.
2. Headache
Effective for tension headaches, migraine headaches, or general fatigue-related headaches.
3. Body Aches and Muscle Pain
Relieves muscle soreness, post-exercise pain, or general body aches caused by infections or inflammation.
4. Joint Pain
Often used to manage mild joint pain or early-stage arthritis discomfort.
5. Toothache
Provides quick relief from dental pain, including post-extraction soreness.
6. Post-surgical Pain
Sometimes used in hospitals as part of pain management post-surgery.
7. Menstrual Pain
Mild to moderate menstrual cramps can also be eased with Dolo 650.

How Paracetamol Dolo 650 Works?
Paracetamol works primarily in the brain and spinal cord (central nervous system) by inhibiting the action of cyclooxygenase (COX) enzymes, particularly COX-3, which are responsible for the production of prostaglandins (chemicals that cause pain and fever).
- For fever: It acts on the hypothalamus, the temperature-regulating center of the brain, and helps bring down elevated body temperature.
- For pain: It blocks the transmission of pain signals in the nervous system, reducing the sensation of pain.
Dosage and Administratio
General dosage for adults:
- One tablet (650 mg) every 4 to 6 hours as needed.
- Maximum dosage: Do not exceed 4 grams (4000 mg) per day (i.e., about 6 tablets).
For children:
- Dolo 650 is not recommended for children below 12 years. Lower-dose pediatric versions of paracetamol (like syrups or 250 mg tablets) should be used based on a doctor’s advice.
How to take:
- Swallow the tablet with water.
- Can be taken with or without food.
- Do not crush or chew unless prescribed.
Side Effects of Dolo 650
When taken in the correct dosage, Dolo 650 is considered very safe. However, excessive or prolonged use can lead to some side effects.
Common side effects:
- Nausea
- Stomach upset
- Skin rash (in rare cases)
Serious (but rare) side effects:
- Liver damage (with overdose)
- Allergic reactions like swelling, difficulty breathing, or rashes
- Low blood pressure or irregular heartbeat in hypersensitive individuals
If you experience any unusual symptoms after taking the medicine, consult a healthcare provider immediately.

Precautions and Warnings
Before taking Dolo 650, consider the following precautions:
1. Liver Problems
If you have liver disease, consult a doctor before taking Dolo 650. Overuse can cause liver failure.
2. Alcohol Consumption
Avoid alcohol while taking this medicine, as it increases the risk of liver toxicity.
3. Pregnancy and Breastfeeding
Paracetamol is generally safe during pregnancy and breastfeeding but should only be used under medical supervision.
4. Kidney Disease
Use with caution in patients with kidney impairment.
5. Drug Interactions
Inform your doctor if you’re taking other medications like blood thinners (e.g., warfarin), anti-epileptic drugs, or antibiotics, as these can interact with paracetamol.
Overdose and Emergency
Taking more than the recommended dose of Dolo 650 can be dangerous and even fatal.
Symptoms of overdose:
- Vomiting
- Abdominal pain
- Confusion
- Yellowing of eyes/skin (jaundice)
- Liver failure
What to do in case of overdose:
Seek immediate medical attention. In hospitals, N-acetylcysteine (NAC) is used as an antidote for paracetamol poisoning.
Storage Instructions
- Store below 25°C (77°F) in a dry place.
- Keep away from moisture, sunlight, and heat.
- Keep out of reach of children and pets.
Conclusion
Dolo 650 (Paracetamol) is one of the most reliable and widely used medicines for fever and mild to moderate pain. Known for its safety profile, fast action, and affordability, it remains a staple in almost every Indian household’s first-aid kit.
However, like all medications, it must be used responsibly. Overuse or misuse, especially in combination with alcohol or other liver-affecting drugs, can lead to serious complications. Always follow the recommended dosage and consult a healthcare provider if symptoms persist.
Disclaimer: This article is for informational purposes only and does not replace medical advice. Always consult a doctor or pharmacist for proper diagnosis and treatment.
Frequently Asked Questions (FAQs)
1. Can Dolo 650 be taken without a prescription?
Yes, it is available over-the-counter in India. However, it’s best to use it with guidance from a doctor, especially for prolonged use.
2. Is Dolo 650 an antibiotic?
No. It is not an antibiotic. It only treats fever and pain, not infections.
3. Can I take Dolo 650 and an antibiotic together?
Yes, it is often prescribed along with antibiotics to manage fever and pain, but always follow your doctor’s advice.
4. Does Dolo 650 make you sleepy?
Paracetamol is non-sedative, so it doesn’t cause drowsiness in most people.
5. Is Dolo 650 safe during COVID-19?
Yes. During the COVID-19 pandemic, Dolo 650 was widely used to manage fever, body aches, and discomfort from vaccination. It is considered safe when taken at recommended doses.
6. Can I take Dolo 650 for cold and cough?
Dolo 650 helps in reducing fever and body ache caused by cold but does not treat cough or nasal congestion. A cold-specific medicine may be required.
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